The widely used diabetes drug metformin comes with a rather unexpected and alluring side effect: it encourages the growth of new neurons in the brain. The study reported in the July 6th issue of Cell Stem Cell, a Cell Press publication, also finds that those neural effects of the drug also make mice smarter. See Also: Health & Medicine Brain Tumor Stem Cells Nervous System Mind & Brain Brain Injury Intelligence Neuroscience Strange Science Reference Neural development Stem cell treatments Diabetes mellitus type 2 Embryonic stem cell The discovery is an important step toward therapies that aim to repair the brain not by introducing new stem cells but rather by spurring those that are already present into action, says the study's lead author Freda Miller of the University of Toronto-affiliated Hospital for Sick Children. The fact that it's a drug that is so widely used and so safe makes the news all that much better. Earlier work by Miller's team highlighted a pathway known as aPKC-CBP for its essential role in telling neural stem cells where and when to differentiate into mature neurons. As it happened, others had found before them that the same pathway is important for the metabolic effects of the drug metformin, but in liver cells. "We put two and two together," Miller says. If metformin activates the CBP pathway in the liver, they thought, maybe it could also do that in neural stem cells of the brain to encourage brain repair. The new evidence lends support to that promising idea in both mouse brains and human cells. Mice taking metformin not only showed an increase in the birth of new neurons, but they were also better able to learn the location of a hidden platform in a standard maze test of spatial learning. While it remains to be seen whether the very popular diabetes drug might already be serving as a brain booster for those who are now taking it, there are already some early hints that it may have cognitive benefits for people with Alzheimer's disease. It had been thought those improvements were the result of better diabetes control, Miller says, but it now appears that metformin may improve Alzheimer's symptoms by enhancing brain repair. Miller says they now hope to test whether metformin might help repair the brains of those who have suffered brain injury due to trauma or radiation therapies for cancer.

Spain's tourism industry is bracing itself for a painful slowdown in bookings this summer, driven by a steep decline in local tourism, according to the country's leading hotel association. Reservations by Spanish vacationers for the month of July are 30% lower than last year, amid persistently high unemployment and a protracted economic recession, said Juan Molas, president of the Spanish Confederation of Hotels and Tourist Accommodations. An influx of visitors from Russia and other countries in Eastern Europe has compensated somewhat for the decline in local tourism, but weak local demand is expected to weigh on an industry that accounts for about 11% of Spain's annual economic output. Hotel owners are concerned that the government may raise the industry's value-added tax to 18% from the current 8%, in a bid to reduce its yawning budget deficit, making Spain less attractive to foreign tourists compared with other less expensive destinations "If the VAT rises to 18%, it will be absolutely catastrophic for the sector," Mr. Molas said at an event Thursday in Madrid. Spain's government is working to secure €100 billion ($126 billion) in aid for its struggling banking sector from the European Union and plans to meet with EU officials next week to discuss new measures to improve its public finances. Prime Minister Mariano Rajoy has already implemented €45 billion in austerity measures, but weak tax revenue threatens to undermine his administration's goal of trimming its shortfall this year to 5.3% of gross domestic product from 8.9% last year. Sentiment in the hospitality industry is at its lowest level since 2009, according to an index developed by the hotel association and consulting firm PwC. Based on a survey of hotel firms, 57% of operators expect international tourism will hold steady this year, while 76% expect domestic tourism to decline. "The parts of the country that will suffer the most are those that cater to national tourists," Mr. Molas said.

Holidaymakers in Spain this summer are facing a surprise new airport tax imposed by the Spanish government as it tries to balance its books. Some airlines are passing the new departure tax on to passengers, even if they booked their flights months ago. Some passengers have received emails telling them either to pay an extra charge of up to seven euros (£6) per person - or to cancel their flights. Other airlines are deciding whether to absorb the cost themselves. The budget airline Ryanair said Spain's 2012 budget, passed into law at the end of June, obliged airlines to pay increased taxes. Spain is implementing drastic measures to try to slash its budget deficit to 5.3% from 8.5% in 2011. It has been promised bailout funds of up to 100bn euros for its banks, but wants to avoid a full state bailout. Retrospective The European travel agents' association ECTAA said the amount of the extra levy varied depending on which airport people used. It said the average rise in the tax was 18.9%, but at some of the larger airports it would almost double. For instance, at Madrid-Barajas the tax would rise from 6.95 euros to 14.44, while at Barcelona's El Prat airport it would rise from 6.12 euros to 13.44. Ryanair said it would pass the cost on to passengers, even those who had already paid in full for their flights, because the tax applied "retrospectively to customers who booked flights before 2 July 2012 and are travelling from 1 July onwards". It said for bookings made on or after 2 July, the increased tax would have been included in the price. The Spanish low-cost airline Vueling is also passing on the cost. It sent emails to passengers giving them seven days to cancel their flight, or the extra payment would be debited automatically from the card they used to book. British Airways and Iberia told the BBC they had not yet decided whether to pass on the cost or absorb it. ECTAA said in a statement it was "dismayed" by the rise, which was imposed "without proper consultation of airport users nor appropriate implementation time". It said travel agents faced a "technical and financial nightmare to recover the extra charge".

a photo series by david eger recreates famous photos and paintings with star wars figurines and handcrafted sets
above: 'troopers raising the flag on iwo jima' (joe rosenthal's 'raising the flag on iwo jima')
all images © david eger
as part of a year-long project '365 days of clones', canadian art teacher david eger has recreated famous photographs and paintings 
using star wars figurines. the scenography is done in real life rather than in photoshop, in a project that was eger's response to his 
new year's resolution to pursue personal photographic endeavours more often.

eger photographed each piece on a date relevant to the original work: the anniversary of the date the photograph was taken
in the case of most contemporary pieces; or the birth or death dates of the artist for images like his recreations of pablo picasso's
'guernica' or leonardo da vinci's 'vitruvian man'.



'troopers atop a skyscraper' (charles c. ebbets's 'lunchtime atop a skyscraper')




'abbey road' (ilan macmillan's 'abbey road' cover shot of the beatles)



'galactic gothic' (grant wood's 'american gothic')



'B.F. boba fett' (cover of film 'E.T. extra terrestrial'), with yoda in bicycle basket



'migrant trooper' (dorothea lange's 'migrant mother' great depression photograph of florence owens)



'a royal kiss' (recreation of the wedding day first kiss of prince william and catherine middleton at the buckingham palace)



'gandhi' (margaret bourke-white's portrait of gandhi spinning cotton)



'million trooper march' (bob adelman's photograph of martin luther king jr.)



eger's setup for the 'million trooper march' recreation



'the cloned kiss' (alfred eisenstaedt's 'the kiss')

Master of cuteness Mark Taylor's images are in demand all over the world for the purr-fect way they capture a softer side to our best-loved animals.

His photographs are a legacy from his late mother Jane Burton who pioneered the style so familiar on calendars in offices and maths teacher classrooms everywhere.

Fosset the kitten with a yellow gosling: Photographer Mark Taylor is famous around the world for his cute shots of animals in unusual poses

Fosset cuddles up to his gosling friend: Mr Taylor's photographs are a legacy from his late mother Jane Burton who pioneered the style

Stanley the kitten with a duckling: Despite the menacing look in Stanley's eyes, Mr Taylor has never had any incidents where one subject ate another

Using a simple clean white background and some unusual animal pairings Mr Taylor's style has seen him make the cover of prestigious wildlife magazine National Geographic.

In this set of heart-warming images Mr Taylor shows why he's one of the best in his field tapping into that desire in us all to see something fluffy.

From ducklings with puppies, to dogs with kittens and even rabbits Mark captures them all on camera as if they were the best and friends.

And thankfully so far he's had no case of any of them eating each other.

Hear me roar: Kittens Stanley and Fosset have a cuddle

Guess who! Stanley holds his paws over Fosset's face as they play

King of the castle: Stanley climbs on top of Fosset

Not just for Christmas: Stanley and Fosset pose inside a gift box

Touch on that: Stanley offers his paw for a fist bump. Right, he poses with a bright red flower

Oh you! Stanley gestures towards the camera as he lies in a hammock

Time for a cat nap: Stanley and Fosset enjoy a snooze

Keeping it in the family: Mr Taylor's daughter Siena, pictured with Stanley, helps to pose the animals for her father's photo shoots

Mr Taylor, 47, creates his images all at his home studio Warren Photographic, in Guildford, Surrey.

His father Kim is a world-renowned wildlife photographer. His mother Jane, who died in 2007 after a brave battle against cancer, was one of the first to use a unique style now so well adopted by her son.

Mr Taylor, a father of one, said: 'There have been a few close shaves when we have put the different animals together, but we often "introduce" the animals to a rabbit in a cage first to gauge the reaction.

'If the dog starts licking its lips we know it might not work out well, and for example it's best not to put a Jack Russell next to a rabbit.

'I have helpers in the studio and some of the animals extras we have here, for example we have six rabbits, but others we have to bring in.

'The key to the photograph is making sure the animals are not doing anything they don't want to do because I think you can tell if they are not enjoying themselves.

'My mother was a pioneer if you like of this idea of using the clean white backgrounds and I like to think I am carrying on her legacy.'

You wanna start something? Stanley goes nose to nose with a Bichon Fris

My big mate: Stanley nuzzles up with Great Dane pup Tia

Where u go? Stanley and Tia have a play

Keeping it in the family Mr Taylor's daughter Siena, 10, is also on hand to pose up with the animals in the pictures.

Mr Taylor, who uses a Cannon 1DS Mark III camera, said that he felt his photographs were so popular because they tap into an desire in us all to relate to animals.

He said: 'I think the fascinating aspect of this type of photography is that it taps into something in us all that sees ourselves and human emotions in our pets and other animals.'

Barclays chief executive Bob Diamond has resigned with immediate effect. The move comes less than a week after the bank was fined a record amount for trying to manipulate inter-bank lending rates. Mr Diamond said he was stepping down because the external pressure on the bank risked "damaging the franchise". Chairman Marcus Agius, who said on Monday he was stepping down, will take over the running of Barclays until a replacement is found. "I am deeply disappointed that the impression created by the events announced last week about what Barclays and its people stand for could not be further from the truth," Mr Diamond said in a statement. He will still appear before MPs on the Treasury Committee to answer questions about the Libor affair on Wednesday. "I look forward to fulfilling my obligation to contribute to the Treasury Committee's enquiries related to the settlements that Barclays announced last week without my leadership in question," Mr Diamond said. Last week, regulators in the US and UK fined Barclays £290m ($450m) for attempting to rig Libor and Euribor, the interest rates at which banks lend to each other, which underpin trillions of pounds worth of financial transactions. Staff did this over a number of years, trying to raise them for profit and then, during the financial crisis, lowering them to hide the level to which Barclays was under financial stress. Prime Minister David Cameron has described the rigging of Libor rates as "a scandal". The Serious Fraud Office is also considering whether to bring criminal charges.

New motoring laws have come into force in France making it compulsory for drivers to carry breathalyser kits in their vehicles. As of July 1, motorists and motorcyclists will face an on-the-spot fine unless they travel with two single-use devices as part of a government drive to reduce the number of drink-drive related deaths. The new regulations, which excludes mopeds, will be fully enforced and include foreigner drivers from November 1 following a four-month grace period. Anyone failing to produce a breathalyser after that date will receive an 11 euro fine. French police have warned they will be carrying out random checks on drivers crossing into France via ferries and through the Channel Tunnel to enforce the new rules. Retailers in the UK have reported a massive rise in breathalyser sales as British drivers travelling across the Channel ensure they do not fall foul of the new legislation. Car accessory retailer Halfords said it is selling one kit every minute of the day and has rushed extra stock into stores to cope with the unprecedented demand. Six out of 10 Britons travelling to France are not aware they have to carry two NF approved breathalysers at all times, according to the company. The French government hopes to save around 500 lives a year by introducing the new laws, which will encourage drivers who suspect they may be over the limit to test themselves with the kits. The French drink-driving limit is 50mg of alcohol in 100ml of blood - substantially less than the UK limit of 80mg.