FREEFALL LIFESTYLE

One of the country's busiest shopping streets has been closed as a man wearing gas canisters stormed into an office and threatened to blow himself up, it was reported. Tottenham Court Road in central London was closed after police received emergency calls at midday. Scotland Yard sent a hostage negotiator to the scene amid reports the man had held people hostage inside the building several floors up. Pictures emerged of computer and office equipment being thrown through one of the office windows. A police spokesman said it was "too early to say if the suspect was armed or indeed had taken any hostages" but businesses and nearby buildings were evacuated. Joaqam Ramus, who works at nearby Cafe Fresco, said before being evacuated: "There was talk of a bomb and somebody having a hostage in a building. "All Tottenham Court Road is closed and so are we - the police told us to shut. "We don't know what it is but it seems someone has a hostage."

Scotland Yard has urged Portuguese authorities to reopen the search for Madeleine McCann as detectives said there are 195 potential leads to finding her alive. The detective leading the Metropolitan Police review said the case can still be solved before officers released a picture of what she might now look like as a nine-year-old. Detective Chief Inspector Andy Redwood said he believes her disappearance was a stranger abduction, as he said there are 195 "investigative opportunities". Police refused to say what evidence they had uncovered to suggest Madeleine is alive. Mr Redwood confirmed that his team of more than 30 officers involved in the case had been out to Portugal seven times, including a visit to the family's holiday flat in Praia da Luz. It will be five years ago next week since the three-year-old went missing as her parents, Kate and Gerry McCann, dined with friends nearby. A spokesman for the McCanns said the family was pleased with the image. Mr Redwood said his 37 officers had dealt with 40,000 pieces of information but the "primacy still sits in Portugal" in the attempt to find her. Commander Simon Foy said: "Most significantly, the message we want to bring to you is that, on the evidence, there is a possibility that she is alive and we desperately need your help today to appeal directly to the public for information to support our investigation." Mr Redwood said "evidence that she is alive stems from the forensic view of the timeline" that there was the opportunity for her to be taken. Investigations show "there do appear to be gaps", he added. Detectives in Portugal are also understood to want the case reopened but must gain judicial approval via the courts.

Commonly prescribed anti-depressants appear to be doing patients more harm than good, say researchers who have published a paper examining the impact of the medications on the entire body. See Also: Health & Medicine Pharmacology Birth Defects Mental Health Research Mind & Brain Depression Disorders and Syndromes Psychiatry Reference COX-2 inhibitor Psychoactive drug Seasonal affective disorder Anti-obesity drug "We need to be much more cautious about the widespread use of these drugs," says Paul Andrews, an evolutionary biologist at McMaster University and lead author of the article, published recently in the online journal Frontiers in Psychology. "It's important because millions of people are prescribed anti-depressants each year, and the conventional wisdom about these drugs is that they're safe and effective." Andrews and his colleagues examined previous patient studies into the effects of anti-depressants and determined that the benefits of most anti-depressants, even taken at their best, compare poorly to the risks, which include premature death in elderly patients. Anti-depressants are designed to relieve the symptoms of depression by increasing the levels of serotonin in the brain, where it regulates mood. The vast majority of serotonin that the body produces, though, is used for other purposes, including digestion, forming blood clots at wound sites, reproduction and development. What the researchers found is that anti-depressants have negative health effects on all processes normally regulated by serotonin. The findings include these elevated risks: developmental problems in infants problems with sexual stimulation and function and sperm development in adults digestive problems such as diarrhea, constipation, indigestion and bloating abnormal bleeding and stroke in the elderly The authors reviewed three recent studies showing that elderly anti-depressant users are more likely to die than non-users, even after taking other important variables into account. The higher death rates indicate that the overall effect of these drugs on the body is more harmful than beneficial. "Serotonin is an ancient chemical. It's intimately regulating many different processes, and when you interfere with these things you can expect, from an evolutionary perspective, that it's going to cause some harm," Andrews says. Millions of people are prescribed anti-depressants every year, and while the conclusions may seem surprising, Andrews says much of the evidence has long been apparent and available. "The thing that's been missing in the debates about anti-depressants is an overall assessment of all these negative effects relative to their potential beneficial effects," he says. "Most of this evidence has been out there for years and nobody has been looking at this basic issue." In previous research, Andrews and his colleagues had questioned the effectiveness of anti-depressants even for their prescribed function, finding that patients were more likely to suffer relapse after going off their medications as their brains worked to re-establish equilibrium. With even the intended function of anti-depressants in question, Andrews says it is important to look critically at their continuing use. "It could change the way we think about such major pharmaceutical drugs," he says. "You've got a minimal benefit, a laundry list of negative effects -- some small, some rare and some not so rare. The issue is: does the list of negative effects outweigh the minimal benefit?"

The mosquito can carry dengue and chikungunya viruses

A mosquito that spreads tropical diseases including dengue fever may be poised to invade the UK because of climate change.

The Asian tiger mosquito has already been reported in France and Belgium and could be migrating north as winters become warmer and wetter.

Scientists have urged "wide surveillance" for the biting insect across countries of central and northern Europe, including the UK.

The mosquito can carry dengue and chikungunya viruses, both of which cause high fevers. The infections usually occur in tropical regions of Africa, Asia and South America.

Scientists led by Dr Samantha Martin, from the University of Liverpool, used climate models to predict how changing conditions might affect Asian tiger mosquito distribution.

They wrote in the Journal of the Royal Society Interface: "Mosquito climate suitability has significantly increased over the southern UK, northern France, the Benelux, parts of Germany, Italy, Sicily and the Balkan countries."

The research shows that parts of the UK could become hot-spots of Asian tiger mosquito activity between 2030 and 2050.

The mosquito has been introduced into Europe from Asia via goods shipments, mainly used tyres and bamboo.

Climate change is now shifting conditions suitable for the insect from southern Europe to central north-western areas.

The mosquito could survive in water butts and vases, and may find winter protection in greenhouses, said the researchers.

British police are still trying to trace £18m allegedly stolen by the Liberal Democrats' fugitive donor Michael Brown, who is expected to be extradited to Britain within the next 10 days. Brown, 46, was in a holding cell near Madrid airport on Sunday, having been deported from the Dominican Republic, where he had been on the run from UK authorities for three years. Brown, who gave £2.4m to the Liberal Democrats before the 2005 general election, is not expected to challenge a formal move to extradite him to London which has already been set in motion. He was convicted of theft and false accounting in his absence in Britain in 2008 and sentenced to seven years in jail. Detectives are still trying to trace around £18m of Brown's stolen money, which had been moved between his accounts in the US, Britain and Switzerland, the Guardian understands. Brown was estimated to have stolen more than £60m in a number of frauds. Most of his assets have been accounted for in property deals, a Bentley, a yacht and the private jet once used to fly senior Lib Dems across the UK. However, more than £18m has not yet been accounted for. "The file at Interpol on Brown and his associates remains open," a source told the Guardian. Brown's return will be another embarrassing development in the long-running saga over the Lib Dems' biggest single donation. The party has refused to compensate any of Brown's victims, claiming it received the money in good faith and spent it on the 2005 election campaign. Lib Dem leader Nick Clegg welcomed Brown's return to Britain but said on Sunday that the party would not be returning his donation because the Electoral Commission had concluded the money had been received in good faith. The deputy prime minister, who pointed out that the donation was made before he was elected to Westminster, told BBC1's Sunday Politics: "I'm very pleased he's coming back to serve his sentence. This is a convicted fraudster. "I should stress that this is something which happened as far as the Liberal Democrats are concerned before I was even an MP, yet alone leader of the Liberal Democrats. What I've been told is that the Electoral Commission in 2009 looked at this exhaustively – as far as the receipt of that money by the Liberal Democrats from one of his companies. They categorically concluded that the money was received in good faith and all the controls, all the checks that should have been made were reasonably made by the Liberal Democrats at the time. If we'd been shown wanting on those accounts then of course we should pay the money back." But Brown's return will increase focus on the Electoral Commission inquiry into Brown's donations. The inquiry failed to call the Lib Dems' former treasurer, Reg Clark, who resigned over Brown in 2005 and warned advisers to the former Lib Dem leader Charles Kennedy that Brown should be treated with extreme caution. One of Brown's victims said the Lib Dems should return the money. Tony Brown, managing partner at law firm Bivonas which represents US attorney Robert Mann who lost more than $5m (£3m), said Brown may be asked to give evidence as part of his client's claim against the Lib Dems. "The Lib Dems have refused to repay this money to our client even though they know that this is the proceeds of crime. The Electoral Commission has failed to investigate this properly in our view. So now that Brown is returning to the jurisdiction, we can investigate again and establish the basis on which the Lib Dems received this money." Brown is expected to appear before a Spanish court to confirm his name and will then appear before an extradition hearing within 10 days. City of London police, who first uncovered Brown's fraud, confirmed his deportation. Detective Superintendent Bob Wishart said: "We hope that him facing justice will bring some closure to the victims who suffered as a result of his frauds." A close friend of Brown's told the Guardian on Sunday that he had arrived in Spain on Saturday after "volunteering" for deportation from the Dominican Republic, where he has been hiding for three years under the name of Darren Nally. "He asked to return to Britain. He is going home to face the music," the friend said. Brown appeared to come from nowhere when the party was paid £2.4m in the runup to the 2005 election from his company 5th Avenue Partners. A fast-talking and brash Glaswegian, he had walked into the party's then headquarters in Cowley Street and offered it money. He was not registered to vote, had no interest in politics and had never been a party member, but said he was giving the money to create an even playing field. Brown wined and dined with Charles Kennedy and other party grandees, and used his private jet to fly Kennedy across the country during the election campaign. Former Lib Dem insiders say he dazzled them with stories of Gordonstoun public school, St Andrews University and his connections with royalty and the US government. The truth was that he had attended his local school and completed a City and Guilds in catering at Glasgow College of Food Technology. He had no US government links – although he was wanted in Florida for cheque fraud. He was arrested in late 2005 after four former clients said he had duped them out of more than £40m in a high-yield fraud. His victims included Martin Edwards, the former Manchester United chairman, who had invested £8m with 5th Avenue Partners. The court would later be told that 5th Avenue Partners was wholly fraudulent and Brown had given money to the Lib Dems to give himself an air of respectability while duping his victims. The party had been used as part of his cover story, a judge said. In June 2008, while awaiting trial, Brown fled and a warrant was issued for his arrest. In the weeks before he disappeared, from his Hampstead bail address in north London, he changed his name on the electoral roll to Campbell-Brown and allowed his hair to turn grey. He travelled to the Dominican Republic where he enjoyed a millionaire's lifestyle while on the run. He lived in gated communities yards from some of the most pristine beaches in the Caribbean, drove a series of 4x4 vehicles and was a regular at exclusive golf courses. In Punta Cana, an exclusive resort on the eastern tip of the island, he could often be seen walking his dog – named Charles, after the former Lib Dem leader. He was arrested in Punta Cana in January on unrelated fraud allegations.

 A SUSPECTED drug trafficker was found by police hiding in a farmhouse loft in Scotland with a bag stuffed with £70,000, a Spanish court was told last week. Ian Donaldson, 32, is accused of helping fund an international drugs ring smuggling cocaine and speed from Spain to Scotland The former amateur racing driver – who drove a Lamborghini with the distinctive Lambo 88 plate – was tracked down to the farm by officers from the Scottish Crime and Drugs Enforcement Agency. Donaldson – who enjoyed a lavish lifestyle in Marbella and Tenerife– is one of six Brits facing court in Madrid accused of making millions from the drugs trade. Detective Inspector James Wallace of the SCDEA told the court: “I arrested him on February 27, 2009. He was hiding in a loft area in a farm building. We also found £70,000 hidden in a bag.” Eight SCDEA detectives gave evidence to the National Court in the Spanish capital last week via a video link from Edinburgh. The court heard Scottish police mounted a surveillance operation after Donaldson, from Renton, Dunbartonshire, was released on bail. Detectives watched him in a series of meetings in Glasgow and Hamilton in April 2009, as he tried to hide the origins of his fortune, prosecutors allege. Donaldson met with fellow accused Mary Hendry and Joseph Campbell and was observed discussing large sums of money and swapping paperwork for a nightclub in Gran Canaria. It was alleged they were secretly plotting to make it look like Donaldson had made some of his wealth from the club. Meetings took place at supermarkets in Glasgow and Hamilton and the Mitchell Library in Glasgow. DI Wallace told the court: “We saw he (Donaldson) was creating a defence for the Spanish charges. “I believe they (Hendry and Campbell) were both subservient to Donaldson, who instructed them on what to do.” The detective said Donaldson and his company IRD Services were also investigated for money- laundering in Scotland. He added: “There is evidence he purchased seven vehicles in Scotland, worth up to £900,000, between 2006 and 2008.” Mary Hendry told the court she only met Donaldson twice for legitimate business meetings. She said: “Joseph Campbell introduced me to Ian Donaldson because I was trying to sell my restaurant. “I met him the next day and he said he was not interested. I never saw him again.” It is alleged Donaldson was the money man for a gang of drug smugglers based in Tenerife and Marbella, led by Glaswegian Ronald O’Dea, 45. The gang are alleged to have spent millions on luxury villas, fast cars and yachts. In October 2008, police seized a a haul of amphetamines worth £660,000 heading to Scotland after stopping a lorry in Oxfordshire. Donaldson, Hendry and O’Dea share the dock in Madrid with fellow Scot James MacDonald, 62, and Londoners Steve Brown, 45, and Deborah Learmouth, 49. The gang face charges ranging from drug-trafficking to money-laundering. They deny all charges. Two other defendants – Brian Rawlings and Joseph Campbell – failed to show up at the trial. The judges will give their verdict at a later date.

Wayne Rooney and England rugby union World Cup winner Matt Dawson are among the new wave of high-profile figures suing Rupert Murdoch's News International over alleged News of the World phone hacking. The England and Manchester United football star, his agent Paul Stretford, Dawson, now a BBC rugby commentator and Question of Sport team captain, actor James Nesbitt and Sir John Major's former daughter-in-law, Emma Noble, are among 46 new phone-hacking cases filed at the high court in London. Times Newspapers, the News International subsidiary that publishes the Times and Sunday Times, is also facing its first civil damages claim, from Northern Ireland human rights campaigner Jane Winter, who is also suing NoW publisher, News Group Newspapers. Winter's claim is related to an article in the Sunday Times in August 2006, her solicitor confirmed. A reference to the article was made in a witness statement she submitted to the Leveson inquiry in February. Winter alleged in evidence to the inquiry that her emails to the former British army intelligence officer Ian Hurst were hacked by NoW. A News International spokeswoman said Winter's case would be "defended vigorously". Others who have filed claims in the past few days seeking damages for alleged invasion of privacy from News Group, the News International subsidiary that published the now-closed Sunday tabloid, include former Conservative cabinet minister and chief whip Lord Blencathra and former Fire Brigades Union general secretary Andy Gilchrist. The list of new claimants also features Michelle Bayford, the former girlfriend of the victim of the 2006 so-called "elephant man" drug trial case. Her then boyfriend, Ryan Wilson, spent three weeks in a coma and lost all his toes and parts of his fingers to gangrene. Another claimant, Anne Colvin, was a witness in the Tommy Sheridan perjury trial. At a case management conference at the high court in London , Hugh Tomlinson QC, representing victims of alleged phone hacking, told Mr Justice Vos that he had 44 new cases filed while two others had submitted their claims via another legal representative. The court also heard that law firm Harbottle & Lewis has a number of "sensitive clients" who wish to remain anonymous. It is expected that up to 200 new claims will be filed over the coming months, Tomlinson told the court in a previous hearing. Claims filed in the past week bring the number of new cases against News International to 46. This figure includes earlier claims filed by public figures including Cherie Booth, Alex Best, the former wife of the late footballer George Best, and Colin Stagg, the man wrongly accused of murdering Rachel Nickell. Others who have filed claims include comedian Bobby Davro, actor Tina Hobley's former husband Steve Wallington, TV personalities Jamie Theakston and Jeff Brazier, the former boxer Chris Eubank, and footballers Peter Crouch, Kieron Dyer and Jermaine Jenas. The cases are part of a second wave of civil actions which Vos is managing following the settlement of more than 50 cases earlier this year including claims by Jude Law, Charlotte Church and Lord Prescott. Tomlinson did not disclose the names of the claimants on Friday, but court documents show that new cases submitted to the high court in the past week bring the number of new actions faced by News International to nearly 50, a number that is expected to rise considerably. Tomlinson told the court that News International had received 100 requests for discovery of preliminary disclosure. He said there were 4,791 potential phone-hacking victims, of which 1,892 had been contacted by the police. The police believed 1,174 were "likely victims". Court 30 in the Rolls Building of the high court was packed, with more than 50 law firms acting for victims. Vos said there were 58 firms of solicitors representing only 100 victims, which he told Tomlinson was "unbelievable". The judge added that he wanted to ensure costs are reduced for claimants. "Many of them have seen the light and have instructed lawyers who have specialist knowledge of this case," said Vos. He suggested possible tariffs of costs for each element of the legal action. This would mean fresh claimants could access to information relating to the News of the World's phone-hacking activity already produced on discovery in earlier cases, without incurring the costs associated with a full action. "I will have no sympathy for outrageous cost estimates," he said. "A claimant is entitled to have a solicitor, but what he is not entitled to have is a solicitor who knows nothing about the case and charges the defendant for that."

Once known as the ‘baddest man on the planet’, his life has taken more than a few dark twists and turns.

But now Mike Tyson has for the first time revealed his lowest point ever in a searingly candid interview.

The former heavyweight champion said that back in 2009 he was in a hotel room with seven prostitutes, a morphine drip in his arm, a pile of cocaine and a bottle of cognac when he began to feel paranoid.

Candid: The former world champion gave his most honest interview yet - revealing the drug-fuelled night that made him turn his life around and get clean and sober

Convinced the women were trying to steal from him he started beating them up and threw them out - to stop them from 'taking his soul'.

‘It was the lowest point of a very low life, but it was my own knockout punch to clean up life, get whole, get well - and I haven’t done anything in three years now. 

‘I’m clean. I’m sober.’

Tyson’s recently swapped the boxing ring for the cabaret stage in a six night comedy show at the MGM Grand Casino in Las Vegas, where some of his biggest fights took place.

World Champion: Mike Tyson lands the knockout punch to the jaw of challenger Larry Holmes during fourth round of the World Heavyweight Championship in Atlantic City 1988

In an interview with Las Vegas Weekly to promote the show, he was asked to talk about the moment he realised he had to turn his life around.

Tyson, 45 said: ‘Laying in bed in a hotel room - I try never to be alone, even if it’s a prostitute, a dog. 

‘This is really dark. I am in my hotel suite, I’ve got seven women there, and I have a morphine drip, and I had my cocaine, and I had my (Viagra like pill) Cialis, I had my marijuana, I had the Hennessy, and I am at my lowest point because I got paranoid and I thought these women were trying to rob me and set me up. 

‘I started beating them. I was in a dark place. There was a purpose, though, because I didn’t want to give them any more of my soul.

‘So this is my devil, this is where I am, I am locked up alone. There is nobody there telling me that I’m doing too much. 

Troubled: Tyson's first marriage to actress Robin Givens fell apart amid allegations of him being violent - he is now married for the third time

Mug shot: In 1992 Tyson was jailed for raping Desiree Washington - a beauty pageant contestant - he was released from prison after three years

‘That is the devil, he won. I kicked them all out. So that was my lowest point. Oh, man. I am just very grateful to be here - my heart should have blown apart. I was sweating wide awake. No more cocaine. No more. Three years clean.’

In his turbulent life Tyson has been married three times, fathered eight children and became the youngest heavyweight champion the world has ever seen at just 20.

But fame ruined him and his troubled upbringing - his mother was a prostitute and he never knew his pimp father - came back to haunt him.

In the interview he claimed to have earned $300million in winnings but admitted that he was so bad with money he was ‘forced to live paycheck to paycheck’.

In 1992, three years after his first marriage to actress Robin Givens fell apart, he was jailed for six years for raping Desiree Washington, a contestant in the Miss Black America pageant.

Released having served three years, he fought Evander Holyfield in the fight that became one of the most notorious bouts in boxing history when he bit part of his opponent’s ear off.

Reflecting on his life Tyson told Las Vegas Weekly that he was now the happiest he has ever been, and is just trying to be a good husband to his third wife, and a good father to his children.

Tyson said: ‘In order to wear the crown, you have to have a miserable life, and that is the one that inherits the crown. 

‘I don’t know, you have to go from the worst to reach the best. I’m just that extreme type of person. That is who I am, the guy that has no limits.’

 The European Parliament has passed a resolution condemning a nationalisation that has strained relations between Spain and Argentina. Argentina has nationalised YPF, wiping out the Spanish firm Repsol's controlling-stake in the oil firm. The resolution asks the European Commission to consider a "partial suspension" of tariffs that benefit Argentine exports into the EU. Shares in Repsol has another decline, falling 2.3% on Friday. Over the week, Repsol stock has lost almost a fifth of its value. MEPs in the European Parliament said the institution "deplores" the decision taken by Argentina and describes it as an "attack on the exercise of free enterprise". Decisions such as that taken by the Argentine authorities "can put a strain on the climate of understanding and friendship needed to reach" a trade agreement between a South American bloc and the EU, it said. The resolution, which is non-binding, received 458 votes in favour, 71 against and 16 abstentions. 'Not valid' It also emerged that Repsol may be obliged to buy a minority shareholder's YPF stake if it ever lost majority control, which Repsol denied. Twenty-five percent of YPF is owned by Argentina's Eskenazi family through its firm, Peterson. Continue reading the main story Nationalising YPF Spain's Repsol has hitherto owned 57.4% of shares with 25.5% belonging to Argentina's Petersen, 0.02% to the Argentine government and 17% traded on stock exchanges The Argentine government proposes to seize 51% of the shares, all of which will be taken from Repsol's stake, leaving the Spanish firm with 6.4% The expropriated shares will in turn be divided between the Argentine government and provincial governors Following the expropriation, Petersen will retain its 25.5% stake and 17% of the shares will continue to be traded Argentina's risky energy seizure According to regulator filings of a 2008 agreement, Repsol must "maintain directly or indirectly through controlled companies an ownership interest greater than or equal to 50.1%". If it does not, Repsol is obliged to buy back the loans used to secure the Eskenazis' shares. But Repsol told the BBC that the expropriation of its stake in YPF had invalidated the agreement. "The agreement is not valid under Spanish law in these conditions," said Kristian Rix, a Repsol spokesman. "The law is unequivocal, there is no debate." Trade war brewing? Spain has threatened retaliation against Argentina over the forced nationalisation of oil firm YPF, raising the prospects of a trade war between the nations. Spanish Trade Secretary Jaime Garcia Legaz said the European Union would intervene over Argentina's seizure of YPF. Argentina is taking over 51% of YPF, wiping out Repsol's 57.4% majority stake. The move has wide support in Argentina but has provoked outrage in Spain. Spain's Foreign Minister Jose Manuel Garcia-Margallo said US Secretary of State Hillary Clinton had also offered support. Repsol has said it wants around $10bn (£6.2bn) for its stake in YPF, but Argentina has said it does not accept that valuation. YPF, Argentina's biggest oil company, was privatised in 1993. Last year it announced huge new finds of shale oil and gas.

 Rupert Murdoch's grip on his media empire was dramatically challenged yesterday after his company was labelled a "toxic shadow state" which launched a dirty tricks campaign against MPs and now faces a salvo of phone-hacking claims in the United States. On a tumultuous day for the media mogul, the lawyer who brought the first damages claims against the News of the World in Britain said he had uncovered new allegations of the use of "dark arts" by News Corp in America and was ready to file at least three phone-hacking lawsuits in the company's backyard. The sense of a legal net tightening around Mr Murdoch and News Corp was heightened by the announcement that he and his son James will testify separately next week before the Leveson Inquiry into press standards during three days of what is likely to be uncomfortable scrutiny of alleged widespread criminality in their British tabloid newspapers. In a separate development, the royal editor of The Sun became the latest journalist on the paper to be arrested on suspicion of making corrupt payments to public officials. The arrest coincided with the publication of an incendiary book on the scandal which levelled new accusations that the NOTW set out on an extraordinary campaign of intimidation of MPs to try to blunt their investigations into its alleged law breaking. Last night senior MPs called for News International (NI) to be investigated by the Commons for potential contempt of Parliament over the claims that members of the House of Commons Culture, Media and Sport Select Committee were targeted by attempts to dig dirt on their private lives. Dial M for Murdoch, written by the Labour MP Tom Watson and The Independent's Martin Hickman, also alleges that: l Rebekah Brooks, the former chief executive of NI, was bugged in her own office shortly before she resigned last summer over the phone hacking of Milly Dowler, the murdered schoolgirl. l On his release from prison, Glenn Mulcaire, the convicted NOTW hacker, allegedly was contracted to give security advice to a private security company, Quest, whose chairman is Lord Stevens, a former Commissioner of the Metropolitan Police. l NI intermediaries approached Mr Watson with a "deal" to "give him" former NOTW editor and Downing Street press chief Andy Coulson but that Ms Brooks was "sacred". NI, which runs Mr Murdoch's British newspapers, said it had no comment to make on the book. At a packed Westminster press conference, Mr Watson, who is a member of the Culture, Media and Sport committee, said the claim that the NOTW set out in 2009 to undermine the MPs investigating it came from Neville Thurlbeck, the NOTW's former chief reporter. In the book, Mr Thurlbeck, who has been arrested in connection with phone hacking, says: "An edict came down... and it was find out every single thing you can about every single member: who was gay, who had affairs, anything we can use." Mr Thurlbeck told The Independent last night that the order to target the MPs, which involved assigning two politicians each to a group of six reporters, had not originated from inside the paper but instead came from "elsewhere inside News International". He insisted that NOTW staff had been reluctant and there was a "degree of procrastination" before the plan was "suddenly and unexpectedly halted about 10 days later". Mr Watson, who has received an apology from NI after he was placed under surveillance, said he believed the campaign was nonetheless successful and had contributed to a decision by the media committee not to demand that Ms Brooks give evidence to it in 2010. He added: "Parliament was, in effect, intimidated. News International thought they could do this, that they could get away with it, that no one could touch them; and they actually did it, and it worked." Labelling News Corp a "toxic institution", he added: "We conclude that the web of influence which News Corporation spun in Britain, which effectively bent politicians, police and many others in public life to its will, amounted to a shadow state." Former Plaid Cymru MP Adam Price, who is gay and was a member of the DCMS committee, is described in the book as having been warned by a Conservative colleague that their private lives would be raked over if they called Ms Brooks to give evidence – "effectively they would delve into our personal lives in order to punish us". Hours after publication of the book, Mark Lewis, the lawyer who has doggedly pursued hacking claims, told a press conference in New York that he was investigating allegations of impropriety at Mr Murdoch's US media companies, including Fox News. He said a high-profile trip to America to prepare claims on behalf of victims whose phones were allegedly hacked on US soil had generated a slew of new allegations about wider use of "dark arts" to obtain private information. He said: "The investigation in the UK began with one claim by one client and look where it is now. While it starts in America with three cases, it seems likely it might end up with more." The allegations will provide an awkward backdrop for the Murdochs to their appearances before the Leveson Inquiry. Rupert Murdoch, who is the first witness before the inquiry to be scheduled for two days of testimony, will be questioned about practices in his British newspapers and whether he had knowledge of those activities. Chris Bryant last night confirmed that he would be asking Parliament to investigate the claims that NI carried out targeted intimidation. Royal editor of The Sun arrested The royal editor of The Sun was arrested yesterday after News Corp handed over information to detectives investigating alleged illegal payments to public officials. Duncan Larcombe, 36, who had previously worked as the newspaper's defence editor, was arrested during an early morning raid at his home in Kent on suspicion of conspiracy to corrupt and conspiracy to cause misconduct in a public office. Officers from Scotland Yard's Operation Elveden also arrested a 42-year-old former member of the armed forces and a woman, 38, at their home in Lancashire. All three were later released on bail. Mr Larcombe was the paper's royal correspondent from 2005 to 2009 before being appointed defence editor for 14 months. He returned to the royal beat last year and led the newspaper's coverage of the wedding of Kate Middleton and Prince William. He was the second Sun defence editor to be arrested during the police inquiry.

A study of mobile phone calls suggests that women call their spouse more than any other person. That changes as their daughters become old enough to have children, after which they become the most important person in their lives. The study has been published in the journal Scientific Reports. It also shows that men call their spouse most often for the first seven years of their relationship. They then shift their focus to other friends. The results come from an analysis of the texts of mobile phone calls of three million people. According to the study's co-author, Professor Robin Dunbar of Oxford University, UK, the investigation shows that pair-bonding is much more important to women than men. "It's the first really strong evidence that romantic relationships are driven by women," he told BBC News. "It's they who make the decision and once they have made their mind up, they just go for the poor bloke until he keels over and gives in!" But the data shows that women start to switch the preference of their best friend from about the mid-30s, and by the age of 45 a woman of a generation younger becomes the "new best friend", according to Professor Dunbar. Continue reading the main story “ Start Quote Human societies are moving back to a matriarchy” Prof Robin Dunbar Oxford University "What seems to happen is that women push the 'old man' out to become their second best friend, and he gets called much less often and all her attention is focussed on her daughters just at the point at which you are likely to see grandchildren arriving," he says. Prof Dunbar also claims that the findings suggest that human societies are moving away from a patriarchy back to a matriarchy. The aim of the project was to find out how close, intimate relationships vary over a lifetime. This kind of anthropological study is normally very difficult to do because it is hard for researchers to get such a big picture of people's lives. But by looking at an at an extremely large mobile phone database, they were able to track these changes extremely accurately. They had access to the age and sex of the callers, who between them made three billion calls and half a billion texts over a period of seven months. Intensely focussed The team wanted to find out how the gender preference of best friends, as defined by the frequency of the calling, changed over the course of a lifetime and differed between men and women. They found that men tend to choose a woman the same age as themselves - which the researchers presumed to be their girlfriend or wife - as a best friend much later in life than women do, and for a much shorter time. This occurs when they are in their early-30s, possibly during courtship, and stops after seven years or so. Women, however, choose a man of a similar age to be their best friend from the age of 20. He remains for about 15 years, after which time he's replaced by a daughter. The pendulum between the two sexes is swinging back towards women, says Prof Dunbar The researchers say that a woman's social world is intensely focussed a on one individual and will shift as a result of reproductive interests from being the mate to children and grandchildren. According to Prof Dunbar, the data suggests that "at root the important relationships are those between women and not those between men". "Men's relationships are too casual. They often function at a high level in a political sense, of course; but at the end of the day, the structure of society is driven by women, which is exactly what we see in primates," he explains. Many anthropologists argue that most human societies are patriarchal on the basis that in most communities men stay where they are born whereas the wives move. But Professor Dunbar and his colleagues are arguing that this only occurs in agriculturally based societies. "If you look at hunter-gatherers and you look at modern humans in modern post-industrial societies, we are much more matriarchal. It's almost as if the pendulum between the two sexes, power-wise, is swinging (back) as we move away from agriculture toward a knowledge-based economy," he says.

They don't spread disease and they can't be sold into sex slavery. Those are just two of the advantages of robot prostitutes, which will be edging out their human competition in the sex tourism market by the year 2050, according to an article published in the journal Futures. The Dominion Post, which found the study, writes that sex tourists will shell out about $10,000 Euros for services ranging from massages and lap dances to intercourse, according to the article. The researchers lay out why this scenario will be the future of sex tourism: Human trafficking, sexual transmitted diseases, beauty and physical perfection, pleasure for sex toys, emotional connection to robots and the importance of sex in Amsterdam are all driving forces. But some are not so sure that robots will be replacing female sex workers any time soon. CBS Las Vegas spoke to Dennis Hof, owner of the Moonlite Bunny Ranch in Carson City, Nev. “Those Australian researchers ought to come to the Bunny Ranch to see what real American sex is like – there’s no way to duplicate it,” Hof told CBS Las Vegas. “At the Bunny Ranch, we say ‘it’s not just the sex, it’s an adventure’ – and often times it’s more about the adventure than it is the sex.”

Rap mogul and entrepreneur Sean 'Diddy' Combs has topped Forbes magazine's annual hip-hop rich list. The star is worth $550 million, according to the publication. New dad Jay-Z comes in second with an estimated $460 million fortune. Coachella festival headliner Dr. Dre, Bryan 'Birdman' Williams and 50 Cent round out the top five.

Qatar signed a deal Monday to buy the operator of four luxury resorts and other properties on the island of Sardinia as the wealthy Gulf emirate looks to bolster ties with Italy. The purchase coincided with a visit to Rome by the country’s emir. It is the latest deal in a European shopping spree that has given the natural-gas rich state a stake in European banks, energy companies and some of the continent’s best known brands. 0 Comments Weigh InCorrections? Personal Post State-owned Qatar Holding, an arm of the country’s sovereign wealth fund, said it will acquire resort operator Smeralda Holding from Los Angeles-based real estate investment firm Colony Capital. The deal includes the Cala di Volpe, Pitrizza, Romazzino and Cervo hotels, a marina and shipyard, a golf club and a 51 percent interest in 2,290 hectares (5,660 acres) of undeveloped land nearby. Qatar Holding plans to keep Smeralda’s existing management, and said Starwood Hotels and Resorts Worldwide Inc. will continue to run the hotels. Financial terms were not disclosed. The deal must still be approved by Italian regulators. The deal was announced as Italian Premier Mario Monti held talks with Qatar’s emir Sheik Hamad bin Khalifa Al Thani at a government villa in Rome. Monti hailed the visit as way for the countries to strengthen their friendship. “I am very happy for this meeting because it was (an) occasion to consolidate a strategic relationship between the two countries,” Monti told a news conference after the talks. The emir told reporters that Qatar’s sovereign fund is looking for ways to invest in Italy. When asked what factors discouraged investment in Italy, the emir said “corruption, first of all,” according to Monti. Among the accords signed Monday was one aimed at boosting efforts to fight graft and crime. Another raises the number of passenger flights between the countries from 14 to 35 weekly, and cargo flights from two to seven, Monti said. Monti promised Italian help to Qatar as it prepares to host soccer’s 2022 World Cup. “Italy has unique know-how and can contribute to the success” of the sporting event, the Italian leader said. Over the past several years, Qatar has used its vast energy wealth to amass a diverse portfolio of European properties. Its holdings on the continent include stakes in Barclays PLC, Credit Suisse Group, Volkswagen AG, and the London Stock Exchange. It acquired stakes in Spanish power utility Iberdrola SA and electric company Energias de Portugal last year. Qatari investors control French soccer team Paris Saint-Germain and Spanish club Malaga, while the logo of state-sponsored nonprofit Qatar Foundation graces the jerseys of another Spanish team, Barcelona.

SURF AIR, a Californian start-up, has a novel business model: for a monthly fee you can fly with the airline as much as you want. Is buffet-style air travel the wave of the future? JetBlue and Sun Country Airlines have both already tried offering all-you-can-fly passes, but so far no carrier has built its business model exclusively on a buffet plan. The idea isn't bad, but some scepticism is warranted. At $790 a month, Surf Air's flying plan will probably only appeal to business travellers who often go to the same places and rich Californians in long-distance relationships. Will that customer base allow Surf Air to make a profit? Maybe: 20m frequent flyers jetted between San Francisco and Los Angeles in 2011, according to the company's numbers. The airline plans to launch with service between Palo Alto, Monterey, Santa Barbara and Los Angeles, but it still needs to secure regulatory approval, according to a company press release. Frequent flyers make up a huge portion of the business-traveller population, and almost every airline relies on business travellers to get (and stay) in the black. There is surely some group of private-jet-sharing business travellers who might be attracted to an all-you-can-jet airline as a cheaper alternative. A lot will depend on how many flights and how much convenience Surf Air can offer, and how quickly it can expand service. The company's promises certainly seem attractive: [Surf Air will offer] its members 30-second booking and cancellations, travel to and from uncongested regional airports, and an easy arrive-and-fly process with no hassle, no lines and no extra fees. It's easy to make promises, though. It's much harder to run a profitable airline. As Gulliver often notes, the American airline sector overall has never really made any money—in fact, total earnings over the entire history of the industry are minus $33 billion. That, of course, suggests that existing airlines might be doing it wrong. Maybe all-you-can-fly really is the way to go. It's at least worth a shot. I'll be eager to see what people think of the final product—assuming regulators give the go-ahead.

It evolved in humans along with intelligence to make them more adept at avoiding danger. A study of 42 people found the worst sufferers of a common anxiety disorder had a higher IQ than those whose symptoms were less severe. Scientists say their findings published in Frontiers in Evolutionary Neuroscience, suggest worrying has developed as a beneficial trait. Psychiatrist Professor Jeremy Coplan, of SUNY Downstate Medical Centre in New York, and colleagues found high intelligence and worry are linked with brain activity measured by the depletion of the nutrient choline in the white matter of the brain. He said: "While excessive worry is generally seen as a negative trait and high intelligence as a positive one, worry may cause our species to avoid dangerous situations, regardless of how remote a possibility they may be. "In essence, worry may make people 'take no chances,' and such people may have higher survival rates. Thus, like intelligence, worry may confer a benefit upon the species." The researchers made the discovery by monitoring activity in the brains of twenty six patients with generalized anxiety disorder (GAD) and eighteen healthy volunteers to assess the relationship between IQ, worry and the metabolism of choline. In the control group high IQ was associated with a lower degree of worry, but in those diagnosed with GAD it was linked with more. The correlation between IQ and worry was significant in both the GAD group and the healthy control group. But in the former it was positive and in the latter negative. Previous studies have indicated excessive worry tends to exist both in people with higher and lower intelligence, and less so in people of moderate intelligence. It has been suggested people with lower intelligence suffer more anxiety because they achieve less success in life. Worrying has also been shown to lessen the effect of depression by countering brain activity that heightens the condition.

Dieters often dismiss them because of their high fat content, but research suggests that snacking on nuts can help keep you slim. A study found that those who consumed varieties such as almonds, cashews and pistachios demonstrated a lower body weight, body mass index (BMI) and waist circumference compared to non-consumers. They were also at lower risk of developing heart disease, type 2 diabetes and metabolic syndrome. Experts are now recommending a daily intake of 1.5 ounces, or three tablespoons of nuts as part of a healthy diet. Lead researcher Carol O'Neil, from Louisiana State University, said: 'One of the more interesting findings was the fact that tree nut consumers had lower body weight, as well as lower body mass index (BMI) and waist circumference compared to non-consumers. 'The mean weight, BMI, and waist circumference were 4.19 pounds, 0.9kg/m2 and 0.83 inches lower in consumers than non-consumers, respectively.' In the study, published in the Journal of the American College of Nutrition, researchers compared risk factors for heart disease, type 2 diabetes and metabolic syndrome of nut consumers versus those who did not consume nuts.

23-year-old self-proclaimed currency trading expert who received a wave of publicity after reportedly spending £125,000 on a single bottle of champagne, has been arrested by City regulators investigating suspected unauthorised trading. Alex Hope, formerly a Wembley stadium catering manager, has sought considerable publicity, setting up his own website – alexhopefx.com – and making a number of media appearances. The Financial Services Authority (FSA) said a 23-year-old had been arrested on suspicion of committing offences under the FSA Markets Act 2000 and the Fraud Act 2006. No one has been charged with an offence. Hope, who was at his flat in east London's Docklands with friends and family, refused to comment on the reports of his arrest. "I can't talk," he said. "I've got no comment whatsoever, to be honest with you ... I don't want to comment on anything." Hope, who claims a typical working day for him stretches from 7am until midnight, generated much publicity last month after reputedly spending more than £200,000 on Britain's most expensive round of drinks at a Liverpool nightclub. He is said to have spent £125,000 on a 99lb double Nebuchadnezzar bottle of Armand de Brignac champagne as well as further bottles of champagne and vodka. Newspaper reports of the revelries claimed guests included Manchester City footballers Joe Hart and Adam Johnson as well as Coleen Rooney, wife of Manchester United's Wayne. A report in the Daily Mail suggested there had been "some scepticism about the receipt, which was released hours after the party". In the same week, Hope financed the inaugural Fast Growth Entrepreneurs Club networking event at the Westbury Gallery in Mayfair, London. The London Stock Exchange authorised the use of its name as a sponsor of the event, attended by about 60 entrepreneurs and investors, but is understood not to have provided funding. In a video interview at the event, featured on Hope's blog, he said: "How I got started in foreign exchange markets was I read a book called Profiting with Forex and also another book How to Get Started in Currency Trading – this was the age of 19 on my journey to work for my old job." Hope said he studied sports science at university and was barred from switching to economics because he did not have an A-level in maths. Undeterred, he taught himself. "In two to three months, I managed to teach myself what I would have learnt from a three-year course," he said. Hope has created his own YouTube showreel in which he says: "You don't see a lot of people my age in the City doing what I do. And I feel I have got a lot of good opinions of the markets which you don't hear from people my age." He featured prominently in a sponsored supplement about spread-betting in the Daily Telegraph last May. "Who would have thought I would become a trader in the City? Certainly not me," he told the paper. "In a year or two, I'd like to set up my own mini hedge fund." Hope said that before discovering his interest in currency trading, he earned £21,000 a year working in catering management at Wembley stadium. He claims to have briefly worked "as an FX and commodity trader" for the Forex Academy, a Slough-based website that provides courses in currency trading. Last year, he said he had taught "nearly 100" of his friends the elements of currency trading. Several companies have been aggressively advertising foreign exchange trading books and courses in recent years, making bold claims about the opportunities on offer in some of the most high-risk financial markets. Offering tuition for a fee, rather than managing other peoples money, is not an activity regulated by the FSA. On Tuesday, regulators and City of London police officers searched an address in east London "in connection with an investigation into a suspected unauthorised foreign exchange trading scheme." Hope last year set up a company called Short Sterling Limited. He and the company's registrars, Caterham-based AML Benson, are the only directors and no accounts have been filed. He gives his address as a block of flats close to the ExCel Centre by Victoria Dock in east London. According to Land Registry filings, he is not the owner of the lease on that flat. There is only one Alexander Hope on the FSA's authorised persons register – a 48-year-old independent financial adviser in Gloucester, with no connection to the Hope believed to be at the centre of the FSA's inquiries. It is not illegal to deal on the foreign exchange markets without FSA authorisation. However, there are circumstances where traders investing other people's funds are required to be registered with and overseen by the regulator. In a recent interview, Hope said: "I use my own money not other people's." Asked for his top tip for investors hoping to make the most out of currency trading, he said: "Sell the euro and buy safe haven currencies (US dollar, Japanese yen, Swiss franc)."

Richard Branson's airline Virgin Atlantic is under mounting pressure to explain how an insider was apparently able to pass the confidential flight details of as many as 70 celebrities to a major paparazzi agency. Emails sent to the Big Pictures agency in 2010 and 2011 contained the flight details of dozens of celebrities, including Madonna, Princess Beatrice and Sienna Miller. Some of the figures alleged to be affected are friends of Sir Richard and his family and the allegations could prove hugely embarrassing for the tycoon, who is known for his close ties to the world of show business. A senior employee is understood to have resigned on Thursday after initial allegations that she passed on the flight details of eight celebrities including the singer Cheryl Cole and her former husband, the Chelsea footballer Ashley Cole, singer Robbie Williams and actress Scarlett Johansson. The airline launched an internal investigation and insisted it had "robust processes in place to ensure that passenger information is protected". But yesterday another cache of emails came to light that suggested that dozens more famous passengers may have been subject to the privacy breach. Emails seen by the Press Gazette contained the flight details of dozens of celebrities ranging from film stars Charlize Theron and Kate Winslet to Top Gear presenters Jeremy Clarkson and James May. The emails, sent over several months, suggest a degree of familiarity between the two correspondents. In one, Big Pictures allegedly wrote to the Virgin insider, understood to be a supervisor of Upper-Class passengers, saying it was "trying to sort you out some money with accounts". One email, reportedly containing details of a return flight from Heathrow to Newark taken by Borat actor Sacha Baron Cohen and his actress wife Isla Fisher, included the comment: "They're in economy!!!!!!" Big Pictures also appears to have been given an anonymous tip-off about a flight taken by people referred to as "Madonna's kids". In a statement issued on Thursday, Virgin Atlantic called the allegations "extremely serious" and said it had launched an immediate investigation. Virgin Atlantic's spokeswoman could not confirm whether Virgin Group chairman Richard Branson would be personally apologising to the celebrities affected and refused to comment any further pending the outcome of an investigation. The allegations are hugely embarrassing for an airline that markets itself as a glamorous alternative to other long-haul carriers and is known to be popular with the rich and famous. Branson is yet to comment publicly. Others who appear to have been affected include Rihanna, Russell Brand, Rob Brydon and Jonathan Ross. Legal experts said that such disclosures may not be a criminal offence. However, solicitors for Ashley Cole and Sienna Miller said they were taking legal instructions over the allegations. No representative of Big Pictures, owned by the former Celebrity Big Brother contestant Darryn Lyons, was available to comment.

Amazon.co.uk, the British division of the firm, is under scrutiny by UK tax authorities for its affairs over a six-year period, beginning in 2004.

The admission by its American parent Amazon.com is a major embarrassment for a company that has come to dominate many Britons’ spending habits since it was launched in 1998.

The company have allegedly not paid any corporation tax between 2010 and 2011

Buried in a submission to the U.S. Securities and Exchange Commission, a federal regulatory agency, it admits to being ‘under examination, or may be subject to examination’ in a long list of countries including Britain, France, Germany, Japan and Luxembourg.

Amazon.co.uk’s latest accounts reveal that it did not pay a single penny of British corporation tax in either 2010 or 2011.

In 2007, a year after the move, it said it had established its European headquarters in Luxembourg, ‘which we expect will benefit our effective tax rate’.

The company which ships thousands of packages in the UK each week moved to Luxembourg in 2006 for tax relief purposes

Last night Richard Murphy, a tax expert and founder of the Tax Justice Network, said: ‘Luxembourg is a tax haven used by lawyers and accountants to help their clients get out of paying tax.’ 

He estimates Amazon’s sales in the UK were around £2.8billion in 2010, which would have resulted in profits of around £125million.

If it had paid corporation tax, charged at 28 per cent in 2010, this would have resulted in a tax bill of £35million.

Corporation tax is one of the biggest sources of income for the Government, used to pay for vital services such as hospitals, schools and care homes.

Last year Amazon made £125m in profit from online sales in the UK

Last month the Chancellor used his Budget speech to attack ‘aggressive tax avoidance’, describing it as ‘morally repugnant’.

Figures from HM Revenue and Customs show Britain is being robbed of around £35billion a year by cheats who refuse to pay their taxes.

Yesterday HMRC said: ‘We can’t discuss Amazon for legal reasons. HMRC applies the tax laws as they apply to multinationals, so the UK receives the tax revenues to which it is legally entitled.

Where there is a high risk of the UK losing out, we move our resources to challenge that risk and HMRC works within the Joint International Tax Shelter Information Centre on a co-ordinated global approach to prevent loss of tax through unacceptable corporate structuring.’

An Amazon spokesman said: ‘Amazon EU serves tens of millions of customers and sellers throughout Europe from multiple consumer websites in a number of languages, dispatching products to all 27 countries in the EU. 

'We have a single European headquarters in Luxembourg with hundreds of employees to manage this complex operation.’

Emma Boon of the TaxPayers’ Alliance said: ‘Instead of getting angry about this, we need to urge the Government to make Britain’s tax system more competitive so that companies, like Amazon, don’t have an incentive to base themselves in Luxembourg.’

GOOGLE AND SORDID REALITY OF TAX AVOIDANCE

Giant American internet companies such as Amazon and Google have made huge inroads into the UK, claiming to be forces for good that give customers access to music, books and information more easily and cheaply. 

The truth is rather less wholesome. Just like the American robber barons of the Edwardian era – Carnegie, Rockefeller and Vanderbilt – they have embarked on a land-grab; not for steel, oil or real estate, but for intellectual and cultural property. 

They are ruthless would-be monopolists – and avoidance of tax is part and parcel of the plunder.

Today’s revelation that the UK tax authorities are investigating Amazon is bad enough, but the situation at Google is arguably even more egregious as it has its hooks deep into the highest echelons of the Government. 

Friends in high places: Rachel Whetstone

David Cameron’s former adviser Steve Hilton is married to Rachel Whetstone, a former head of communications at Google, who was also godmother to the Prime Minister’s late son Ivan. 

And only a few days ago, Chancellor George Osborne was hobnobbing with Google bigwigs at the opening of the ‘Google Campus’ in east London, a new centre meant to serve as a hub for fledgling high-tech firms, giving it the glow of his official approval.  

For all his talk of a clampdown on ‘morally repugnant’ tax avoidance, Mr Osborne is behaving like an impotent bystander as Amazon and Google trample over the crumbling British high street and raze our creative industries to the ground.

As well as minimising its corporation tax in the UK, Amazon also uses tax dodges to reduce VAT payments to Her Majesty’s Revenue and Customs, with VAT on its e-books payable at the Luxembourg rate of just 3 per cent, rather than the rate here of 20 per cent. 

For  or its part, Google has shielded itself from the British taxman by locating its international operations in Ireland, where the corporation tax rate is a mere 12.5 per cent, around half that in Britain. 

Even that rock-bottom Irish rate, however, is not low enough to satisfy the company and its wealthy founders.

It has deployed complex  techniques known to tax experts as a ‘Double Irish’ or a ‘Dutch Sandwich’ to funnel profits to the white sands of Bermuda, via the Netherlands. 

The result: Google, which makes much of its money from advertising, racked up sales of £2.1billion in the UK, but paid a mere £5million of tax, or a rate of less than a quarter of one per cent.

Other achingly trendy American technology companies embraced by the UK consumer are also adept at keeping their tax payments down.

Apple, whose British stores are mobbed every time it produces a new iPad or iPhone, has stashed some £40billion in overseas subsidiaries, including the British Virgin Islands tax haven. It also has significant operations in Ireland, including a production facility.

Facebook, the social networking site, has also set up shop in Dublin to avail itself of the lenient tax regime available on the banks of the Liffey.

Both Google and Amazon have wormed their way into the affections of much of the British public. They have painstakingly cultivated the image of being trendier, more glamorous and more innovative than traditional businesses. 

Yet the sordid reality of tax avoidance, to swell the corporate coffers at a time when many of their own customers are fearful and struggling to make ends meet, is starkly at odds with these carefully constructed facades.

Sales of the two most popular prescription painkillers in the United States have exploded in new parts of the country, an Associated Press analysis shows, worrying experts who say the push to relieve patients' suffering is spawning an addiction epidemic. Drug Enforcement Administration figures show dramatic rises between 2000 and 2010 in the distribution of oxycodone, the key ingredient in OxyContin, Percocet and Percodan. Some places saw sales increase sixteenfold. Meanwhile, the distribution of hydrocodone, the key ingredient in Vicodin, Norco and Lortab, is rising in Appalachia, the original epicenter of the U.S. painkiller epidemic, as well as in the Midwest. The increases have coincided with a wave of overdose deaths, pharmacy robberies and other problems in New Mexico, Nevada, Utah, Florida and other states. Opioid pain relievers, the category that includes oxycodone and hydrocodone, caused 14,800 overdose deaths in 2008 alone, and the death toll is rising, the Centers for Disease Control and Prevention says. Across the U.S., pharmacies received and ultimately dispensed the equivalent of 69 tons of pure oxycodone and 42 tons of pure hydrocodone in 2010, the last year for which statistics are available. That's enough to give 40 5-mg Percocets and 24 5-mg Vicodins to every person in the United States. The DEA data records shipments from distributors to pharmacies, hospitals, practitioners and teaching institutions. The drugs are eventually dispensed and sold to patients, but the DEA does not keep track of how much individual patients receive. The increase is partly due to the aging U.S. population with pain issues and a greater willingness by doctors to treat pain, said Gregory Bunt, medical director at New York's Daytop Village chain of drug treatment clinics. Sales are also being driven by addiction, as users become physically dependent on painkillers and begin "doctor shopping" to keep the prescriptions coming, he said. "Prescription medications can provide enormous health and quality-of-life benefits to patients," Gil Kerlikowske, the U.S. drug czar, told Congress in March. "However, we all now recognize that these drugs can be just as dangerous and deadly as illicit substances when misused or abused." Opioids like hydrocodone and oxycodone can release intense feelings of well-being. Some abusers swallow the pills; others crush them, then smoke, snort or inject the powder. Unlike most street drugs, the problem has its roots in two disparate parts of the country -- Appalachia and affluent suburbs, said Pete Jackson, president of Advocates for the Reform of Prescription Opioids. "Now it's spreading from those two poles," Jackson said. A few areas that include military bases or Veterans Affairs hospitals have seen large increases in painkiller use because of soldier patients injured in the Middle East, law enforcement officials say. Experts worry painkiller sales are spreading quickly in areas where there are few clinics to treat people who get hooked, Bunt said. In Utica, New York, Patricia Reynolds has struggled to find treatment after becoming dependent on hydrocodone pills originally prescribed for a broken tailbone. The nearest clinics offering Suboxone, an anti-addiction drug, are an hour's drive away in Cooperstown or Syracuse. And those programs are full and are not accepting new patients, she said. "You can't have one clinic like that in the whole area," Reynolds said. "It's a really sad epidemic. I want people to start talking about it instead of pretending it's not a problem and hiding."

 Trolling Could Get You 25 Years in Jail in Arizona One of the Internet's basic tenets—the right to be as much of a myopic, infantile asshat as humanly possible—is currently under attack in Arizona. A sweeping update to the state's telecommunications harrasment bill could make naughty, angry words a Class 1 misdemeanor. Or worse. It's a dangerous precedent, yet another bill written and supported by legislators who fundamentally don't understand the nature of the internet. And I'm not just being a, well, you know. Arizona House Bill 2549 passed both legislative houses last Thursday and is now awaiting approval from Arizona's governor Brewer. The statute states that: "It is unlawful for any person, with intent to terrify, intimidate, threaten, harass, annoy or offend, to use a ANY ELECTRONIC OR DIGITAL DEVICE and use any obscene, lewd or profane language or suggest any lewd or lascivious act, or threaten to inflict physical harm to the person or property of any person." Emphasis added. If the electronic devices and means are employed to stalk a victim, the penalty bumps up to a Class 3 felony. For those not intimately familiar with Arizona penal law, a Class 1 misdemeanor is punishable by a $2,500 fine and up to six months in jail (it's the most aggressive misdemeanor charge the state can bring). A Class 3 felony, meanwhile, carries a minimum sentence of 2.5 years for non-dangerous offenders with no prior record. And a max of 25 years in jail. Opponents of the bill argue that the wording is overly broad and could easily be interpreted to include not just one-on-one communications but public forums like 4Chan, Reddit, and anywhere else that allows commenting. You thought the banhammer was bad? Try handcuffs. It could also have a chilling effect on free speech by prohibiting shocking or "profane" language online. And since the bill stipulates that the offense only has to occur on Arizona soil (since a Facebook comment is definitely a geographic place, right?) that basically puts the entire Internet on notice. The bill's supporters argue that the steps are necessary to prevent online bullying. Despite the public outcry, the bill has seen very little resistance from elected officials. However, given how well Arizona's other recent, short-lived, and generally draconian propositions—-including its racial profiling, anti-gay adoption, and anti-immigration bills—-have fared, House Bill 2549 might not be a law for long, assuming Governor Brewer even signs it.

U.S. Food and Drug Administration issued new safety information about these cholesterol-lowering drugs that are prescribed to millions of Americans to lower the risk of heart disease. If you're among them, you should understand what the FDA's new guidance means for your health. "Before anyone gets too concerned, you should know that statins are so widely used because they have a long track record of safety and effectiveness," says Dr. Mark Taber, a cardiologist with SSM Heart Institute at St. Joseph Health Center. "All in all, statins have a very high benefit to risk ratio. The widespread use of the drugs, when indicated, probably accounts to a significant degree for the improvement in life expectancy in this country." The FDA called attention to the threat of liver damage as a rare side effect of statins and advised that regular liver enzyme testing is no longer considered useful in predicting or preventing liver injury. "Actually, in general they liberalized the follow up needed for liver function tests on patients taking statins, due to the very low incidence of true liver issues," Taber says. The main warnings related to a slightly higher incidence of developing diabetes while on statins, and a poorly substantiated claim that statins could result in cognitive impairment. Taber points out that cognitive problems, such as confusion or memory problems, were not documented in clinical studies, only by patient reports to the FDA website. "By stating these concerns, the FDA is raising awareness about the potential side effects of statins, but cardiologists already know that there are inherent risks, and we monitor patients appropriately to help ensure that side effects do not occur or are dealt with quickly," Taber notes. "If there is any evidence of a side effect that could be problematic, we can change the medication. But the fact remains that it's important to decrease risk of heart disease, and for many people statins are needed when diet and exercise alone don't result in acceptable cholesterol levels." Whenever a new prescription medication is started, you should look over the package insert to learn about potential side effects. Signs of liver damage, for instance, include fatigue, loss of appetite, right upper abdominal pain, dark urine and jaundice. Any of these symptoms should be reported to your doctor for evaluation. It is important to remember that you should not stop taking a medication without consulting your doctor first. Discontinuing use of a prescribed drug can be far more dangerous than the side effect you're worried about. "All the side effects listed by the FDA are rare, and the risk of heart attack is far more concerning," Taber says. "Some patients may need extra monitoring or may need to try more than one statin before we find the optimal choice, but in general statins are very well tolerated and don't cause problems for the people who take them." The advice above is universal when it comes to your health. Concerns should be discussed with your doctor, and decisions should always be made as part of a team approach to creating a healthy life.

John Holliday had been on a higher 40mg dose of cholesterol pills for only a few weeks when he started to lose his concentration. ‘I’d be watching TV and suddenly find myself unable to follow the plot of a drama,’ says John, 52, a telecoms project manager who lives in Southend-on-Sea, Essex, with his wife Jill, 51, and their two children Adam, 20, and Emma, 16. ‘I’d have to read the same page of a book over and over because I couldn’t take any information in. ‘I’d always been known for my amazing memory — I was great on trivia and had total recall of events that happened 20 years ago, but suddenly I couldn’t remember things and my brain felt fuzzy.’ Just like up to seven million other people in Britain, John had been prescribed a statin to lower his blood cholesterol levels. The drugs are credited by the British Heart Foundation as contributing towards the dramatic 50 per cent fall in deaths from heart attacks in the past ten years. But while there is consensus that statins are lifesavers for people who have previously had a heart attack, concern is growing over their debilitating side-effects. They include muscle weakness, depression, sleep disturbance, sexual dysfunction, muscle pain and damage, gastro-intestinal problems, headaches, joint pains and nausea. Now, official bodies here and in the U.S. have ordered that the drugs must carry warnings for cognitive problems, too. Worryingly, it’s claimed GPs are failing to warn patients of the effect statins can have on the mind — meaning they may mistake them for signs of ageing or Alzheimer’s. ‘When I went back to my doctor after six weeks for a blood test, I told him how dreadful I was feeling,’ says John. ‘But he just said all drugs had side-effects and didn’t mention reducing the dose.’ It's claimed GPs are failing to warn patients of the effect statins can have on the mind - meaning they may mistake them for signs of ageing or Alzheimer's Things came to a head when a friend showed John an electrical circuit he’d built for his car. ‘I’d worked with circuits since I was 16 but it made no sense,’ he says. So John insisted on seeing his doctor again and repeated his concerns about his rapidly declining memory. This time the GP told him he could start on another type of statin when he felt well enough, and so John stopped taking the drugs immediately. ‘It took a few months, but gradually my memory returned and I’ve got my concentration back. I can’t say for sure statins caused these problems, but it seems like too much of a coincidence.’ Earlier this year, the Food and Drug Administration (FDA) in the U.S. ordered statins must carry warnings that some users have reported cognitive problems including memory loss, forgetfulness and confusion. This followed a decision by the UK’s Medicines Healthcare Regulatory Agency (MHRA) to add memory problems to the list of  possible statin side-effects in late 2009. The FDA said reports about the symptoms were from across all statin products and age groups. Those affected reported feeling fuzzy or unfocused in their thought process — though these were found to be rare and reversible. The FDA also warned, following U.S. research, that patients on statins had a small excess risk of developing Type 2 diabetes — but stressed that the benefits of taking a statin still outweigh this. The MHRA had 2,675 reports for adverse drug reactions connected with statins between 2007 and 2011. Officially, side-effects are rare —affecting only 1 per cent of people on the pills — but some doctors say they are under-reported. Dr Malcolm Kendrick, a GP and author of The Great Cholesterol Con, says he frequently sees patients suffering from mental confusion in his job in hospital intermediary care for the elderly. ‘Many of the patients I see will have been admitted to hospital after a fall or similar crisis,’ he says. ‘If they appear confused I’ll often advise taking them off statins to see if it has any effect — in my experience, about 10 to 15 per cent of people who appeared to have memory problems experienced an improvement in their memory symptoms after being taken off the drug. ‘I had one dramatic case where a lady was admitted to hospital on 40mg a day of simvastatin with such poor memory function her family asked me about power of attorney. 'I suggested taking her off statins and within a week her memory had returned to normal. She went home a fit and independent 83-year-old.’ Dr Kendrick says cholesterol is the main constituent of synapses (structures that allow signals to pass between brain cells and to create new memories) and is essential for brain function. ‘It is still not proven that statins have a significant effect on mortality — it has been calculated that a man who has had a heart attack who took a statin for five years would extend his life by only 14 days. 'Too many statins are being given to people at low risk. ‘Even in the highest risk group you need to treat 200 people a year with statins to delay just one death. 'One day the harm these drugs are doing is going to be obvious — the benefits are being over-hyped and the risks swept under the carpet.’ While Dr Kendrick’s controversial view is in the minority, one large review of 14 studies by the London School of Hygiene and Tropical Medicine, published by the highly respected Cochrane Library last year, concluded there was ‘little evidence’ cholesterol-lowering drugs protect people who are not at risk of heart disease. This review has been criticised by other doctors who say side-effects are rare and that there are still benefits even for people at lower risk who do not have established heart disease. These defenders of statins include Professor Colin Baigent of the Clinical Trial Service at Oxford University, who published research in 2010 showing statins reduced deaths from all causes by 10 per cent over five years. ‘There is relatively little evidence of cognitive impairment — what evidence there is all comes from observational studies.  ‘People read about side-effects and then put two and two together and blame the statins for their muscle pain or other health problems — it’s just not reliable evidence. ‘If you look at the best-quality randomised controlled trial where patients don’t know if they are taking a statin or placebo, there is no evidence of memory problems. 'Even the FDA says the risks of cognitive problems are very small and go away when statins are discontinued. ‘We’re in danger of forgetting just how effective these drugs are.’ Dr Dermot Neely of the charity Heart UK, and lead consultant at the Lipid and Metabolic Clinic at the Royal Victoria Infirmary in Newcastle, agrees side-effects with statins are rare. ‘I’ve been dealing with patients on statins since 1987 and I can count on the fingers of one hand the number whose memory symptoms turned out to be caused by statins.’ However, he said he often saw patients who had not been told about side-effects. ‘It’s important GPs are clear about the drugs statins can interact with, such as certain antibiotics, as this can get overlooked. ‘If a patient notices an adverse effect after starting statins, they should discuss this with their GP —but not stop their drugs suddenly because this can be dangerous.’ Sonya Porter, 73, decided to stop taking statins after her memory problems became so bad that she walked away from a cashpoint leaving her money behind. ‘I was permanently fuzzy-headed and just couldn’t seem to concentrate,’ says Sonya, a retired PA from Woking, Surrey. Then I started to get scared I might have Alzheimer’s. After reading about memory problems associated with statins, I thought it was at least a possibility. I decided to come off the pills to see if it made any difference. ‘I didn’t ask my GP, I just did it — I’d rather die of a heart attack than Alzheimer’s disease. Within a month I felt normal again and didn’t have any problems with memory. ‘I’m terrified that I could have been misdiagnosed with Alzheimer’s.’ John Holliday is also reluctant to go back on statins. ‘I wouldn’t rule it out completely — my latest test showed my cholesterol levels have gone up,’ he says. ‘But on balance, I’d rather take my chances with heart disease than feel as confused as that again. It’s all very well living slightly longer — but it’s about quality of life, too.’